Comments on: MAOI patch approved http://onthepharm.net/2006/03/emsam-selegiline.html Life on the pharm Mon, 26 Jul 2010 18:29:42 +0000 hourly 1 http://wordpress.org/?v=3.0 By: marie http://onthepharm.net/2006/03/emsam-selegiline.html/comment-page-1#comment-185857 marie Mon, 26 Jul 2010 18:29:21 +0000 http://onthepharm.net/2006/03/emsam-selegiline/#comment-185857 yes there are…I am one of them.<br>phenelezine has been the only antidepressant that has offered me any relief. However, after some time of using it, the side effects begin to outweigh its benefits. This is partly because I have had some liver disease in the past and it is therefore difficult for me to metabolize many drugs.<br>I have been hoping for this for a very long time.<br>Yes, the diet restrictions can be a pain. But even more troublesome is the drug having to go through my whole system.<br>A patch, of course, would bypass that.<br>Unfortunately, I am in Canada and have not been able to find any info here.<br>I don’t think it is approved here.<br>any feedback would be welcomed<br>Marie yes there are…I am one of them.
phenelezine has been the only antidepressant that has offered me any relief. However, after some time of using it, the side effects begin to outweigh its benefits. This is partly because I have had some liver disease in the past and it is therefore difficult for me to metabolize many drugs.
I have been hoping for this for a very long time.
Yes, the diet restrictions can be a pain. But even more troublesome is the drug having to go through my whole system.
A patch, of course, would bypass that.
Unfortunately, I am in Canada and have not been able to find any info here.
I don’t think it is approved here.
any feedback would be welcomed
Marie

]]> By: RJS http://onthepharm.net/2006/03/emsam-selegiline.html/comment-page-1#comment-65 RJS Wed, 21 Jun 2006 18:30:46 +0000 http://onthepharm.net/2006/03/emsam-selegiline/#comment-65 Hello Tom, thanks for your reply. I think you misunderstand; the medical profession recognizes that anti-depressants aren't effective in everyone. Most drugs aren't, but my skepticism isn't over the efficacy of the patch, but rather the safety of MAOIs and the viability of this drug financially. Obviously my experience is anecdotal, but we fill maybe one prescription for an MAOI <em>per year</em>. I'm sure the numbers are higher in cities, but this is a tiny niche for a drug. MAOIs are a tiny part of the anti-depressant market compared to SSRIs, and the medical community's reluctance to use them is due to the numerous side effects and drug interactions associated with them. Because Emsam is transdermal, many of the <a href="http://en.wikipedia.org/wiki/First_pass_effect" rel="nofollow">first-pass effects</a> are eliminated, which gets rid of many of the dietary restrictions associated with MAOIs (for example), but the class of drugs as a whole still has a (rightfully-deserved) stigma attached to them which will likely limit the real-world impact of this drug, for better or worse. Hello Tom, thanks for your reply.

I think you misunderstand; the medical profession recognizes that anti-depressants aren't effective in everyone. Most drugs aren't, but my skepticism isn't over the efficacy of the patch, but rather the safety of MAOIs and the viability of this drug financially. Obviously my experience is anecdotal, but we fill maybe one prescription for an MAOI per year. I'm sure the numbers are higher in cities, but this is a tiny niche for a drug.

MAOIs are a tiny part of the anti-depressant market compared to SSRIs, and the medical community's reluctance to use them is due to the numerous side effects and drug interactions associated with them. Because Emsam is transdermal, many of the first-pass effects are eliminated, which gets rid of many of the dietary restrictions associated with MAOIs (for example), but the class of drugs as a whole still has a (rightfully-deserved) stigma attached to them which will likely limit the real-world impact of this drug, for better or worse.

]]> By: Tom Fontana http://onthepharm.net/2006/03/emsam-selegiline.html/comment-page-1#comment-61 Tom Fontana Wed, 21 Jun 2006 13:57:25 +0000 http://onthepharm.net/2006/03/emsam-selegiline/#comment-61 Considering that SSRI's have been shown to be effective only 40% of the time at their best, I would say that this patch will initially have a large market. As someone that has been treated with SSRI's for 17 years, only to find them currently ineffective, I will jump at the chance to try this patch. It's time for the medical profession to stop diefying SSRI's. There is a great need for new or improved antidepressant medications. Tom Fontana Considering that SSRI's have been shown to be effective only 40% of the time at their best, I would say that this patch will initially have a large market.

As someone that has been treated with SSRI's for 17 years, only to find them currently ineffective, I will jump at the chance to try this patch.

It's time for the medical profession to stop diefying SSRI's. There is a great need for new or improved antidepressant medications.

Tom Fontana

]]> By: marie http://onthepharm.net/2006/03/emsam-selegiline.html/comment-page-1#comment-6 marie Thu, 18 May 2006 17:17:25 +0000 http://onthepharm.net/2006/03/emsam-selegiline/#comment-6 yes there are…I am one of them. phenelezine has been the only antidepressant that has offered me any relief. However, after some time of using it, the side effects begin to outweigh its benefits. This is partly because I have had some liver disease in the past and it is therefore difficult for me to metabolize many drugs. I have been hoping for this for a very long time. Yes, the diet restrictions can be a pain. But even more troublesome is the drug having to go through my whole system. A patch, of course, would bypass that. Unfortunately, I am in Canada and have not been able to find any info here. I don’t think it is approved here. any feedback would be welcomed Marie yes there are…I am one of them.
phenelezine has been the only antidepressant that has offered me any relief. However, after some time of using it, the side effects begin to outweigh its benefits. This is partly because I have had some liver disease in the past and it is therefore difficult for me to metabolize many drugs.
I have been hoping for this for a very long time.
Yes, the diet restrictions can be a pain. But even more troublesome is the drug having to go through my whole system.
A patch, of course, would bypass that.
Unfortunately, I am in Canada and have not been able to find any info here.
I don’t think it is approved here.
any feedback would be welcomed
Marie

]]> By: Judy Aylvia http://onthepharm.net/2006/03/emsam-selegiline.html/comment-page-1#comment-5 Judy Aylvia Thu, 18 May 2006 17:14:40 +0000 http://onthepharm.net/2006/03/emsam-selegiline/#comment-5 I have been using an Maoi inhibiter for about 8 years. I have tried all the other new and old drugs and they either did not work or I could not tolerate the side effects. I am anxios to try the patch so I can eat like a normal person. I don’t go to restauranst often because there is so little I can eat. I am sure there a feww people like me that MAOIs are a lifesend - literly. I have been using an Maoi inhibiter for about 8 years. I have tried all the other new and old drugs and they either did not work or I could not tolerate the side effects. I am anxios to try the patch so I can eat like a normal person. I don’t go to restauranst often because there is so little I can eat.

I am sure there a feww people like me that MAOIs are a lifesend – literly.

]]>