Combining phages and antibiotics
Most talk of phages in the experimental sense is done in terms of monotherapy, from what I've seen. There's not a whole lot of talk about using them in conjunction with current antibiotics, at least not in this fashion:
Experiments in mice revealed that 75% of those infected with a lethal dose of Pseudomonas survived if the antibiotic gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164).
This is sort of nifty in a non-revolutionary sort of way. I've written here before about my love of phages and how I think they're going to be the next "big thing" in infectious disease, this possible new atun antibiotic notwithstanding, so any modern literature concerning phages is a good thing.
The question is whether or not phage cocktails will be considered biologic drugs when they are made available… (Since it's only a matter of time.)
[tags]Medicine, pharmacy, antibiotics, bacteriophages, phage therapy[/tags]
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Comment by Brandon — February 1, 2007 @ 3:59 am