Comments on: And thus it begins: Xyzal

By: frustrated

frustrated — Sat, 13 Mar 2010 17:06:35 +0000

Worked wonders for my itching. Nothing OTC worked long enough including zyrtec. Just remember to take at bed time. Doctor said if the problem is related to histamine, this works great. Text XYZAL to 62900 to receive a text coupon. I paid just $25 for my prescription.

By: Theresa

Theresa — Thu, 27 Aug 2009 16:56:13 +0000

If anyone here is suffering from CHRONIC HIVES

You need to take Doxepin

Ask your doctor about it. It will help you.

By: laura dollieslager

laura dollieslager — Thu, 06 Aug 2009 14:58:30 +0000

I'm trying to get PA for Xyzal which worked way better for me than Zyrtec. I also take celexa because my insurance wouldn't pay for lexapro and understand the mirror image thing. Celexa works just as well for me. But with the antihistamine I have a hypothesis and I'd like feedback. I've got lots of allergies and have taken every antihistamine and after awhile they stop working – some kind of tolerance I suppose. So could it be possible that the new drug somehow works when the nearly identical drug has stopped working?

By: Angela

Angela — Sun, 18 Jan 2009 06:35:46 +0000

I have had Chronic Hives for a few years. No amount of anti-histamines would help. I took zyrtec during the day and atarax at night with no relief. I do have thyroid antibodies with normal TSH. After finding an article regarding thyroid antibodies and Chronic Hives, I convinced a Dr. to try synthroid treatment to get rid of the hives. This resulted in me being hive free for 9 months – I was even able to tolerate the things I was found to be ever so slightly allergic to – that before synthroid caused Horrible reactions that would rusult in horrible hives that lasted for days and inability to breathe.

The hives recently returned and my synthroid was increased which has resulted in alleviation of the hives once again and my TSH is still within safe range.

I really don't know why everyone with chronic hives isn't tested for thyroid antibodies and subsequently treated with supression therapy if they test positive for thryoid antibodies.

Xyzal once released did reduce the severity of hives while zyrtec did nothing.

By: Chris

Chris — Thu, 11 Dec 2008 15:05:40 +0000

OK, so is there anything about Zyrtec being much more sedative than Xyzal? My allergy doc prescribed Xyzal with Singular and gave me samples to try for a couple weeks to make sure they worked. Everything worked great, except my insurance required me to use Zyrtec before they would cover Xyzal, so I switched. They both seem to handle my allergies the same, except I've noticed a huge increase in drowsiness and sleeplessness with Zyrtec. (I'm one of those people that drowsiness actually keeps me up instead of helping me sleep) Is this common? There was drowsiness with Xyzal, but nothing close to this extreme. So far I'm thinking I'd rather fork over the extra cash if it means I don't have to wake up in the middle of the night and not be able to go back to sleep for an hour or more every night.

By: Another rebranding: Zyrtec, but costs 1200% more « I have a blog?

Another rebranding: Zyrtec, but costs 1200% more « I have a blog? — Thu, 27 Nov 2008 03:32:21 +0000

[...] http://onthepharm.net/2007/10/levocetirizine-pointless-drug.html Posted by ludditeandroid Filed in Uncategorized ·Tags: ACTIVE ISOMER, GENERIC DRUG UPDATE, OTC, THIS IS WHY WE CAN'T HAVE NICE THINGS, UNETHICAL TAINTBADGERS, XYZAL, ZYRTEC [...]

By: rachel

rachel — Fri, 12 Sep 2008 00:10:45 +0000

Xyzal works. I'm allergic to any tree you can name and all types of grass. I was on Claritin back when it wasn't OTC, then I was on Singulair and then I was on Zyrtec. And I've always been on a nasal spray. My allergist put me on Xyzal about five weeks ago and I CAN BREATH!! I can walk through a park with tons of grass growing everywhere and I don't sneeze! It's truly amazing. I don't think I'll ever stop taking Xyzal. It has finally provided me with the relief I have been searching for.

Xyzal. Works.

By: Luciano

Luciano — Wed, 10 Sep 2008 18:36:17 +0000

I have been fighting hives for 3yrs now. I was hospitolized once. I notice everytime I catch a cold here they come. I was on prednisone for a year and a half. Been through many test and they cant find a thing wrong with me. I have been on all of them. Atarax, cetrizine, loratine, doxipin, benadryl, Zantac and now Xyzal. Xyzal works. It works faster than zyrtec. I never want to be back on prednisone… ever. I also take supplements like bee pollen (not allegic to bees). It is suppose to be a natural anti-histamine. GNC is the chapest place to get it. I have lost hope. Doxipin works but it makes it hard to get out of bed. One comment on prednisone. Mood swings occur just because its a steroid. I had them bad too. Almost caused me my marrige.

By: Rosalind

Rosalind — Fri, 05 Sep 2008 19:54:24 +0000

I am normally sceptical of "the new, latest, greatest" drug but this time it's different. For years I've used Zyrtec, and its generic,plus Singulair at night. I only made the switch to Xyzal last week when my doc gave me some samples, warning me that the ragweed pollen was especially bad this year. Apart from the benefit of fewer sneezes and improved breathing, I was delighted to find that my eyes are no longer painful. Two different eye-doctors gave me RXs for expensive drops and creams without mentioning that allergies might be the root of the problem. This morning was the first time in many months that I have needed NO eyedrops. I'm so glad I tried something new. Now I'm going to try a new inhalant, Xopenex.

By: Theresa

Theresa — Tue, 12 Aug 2008 13:36:37 +0000

Yes, thyroid problems can cause hives and are associated with them. Anytime our body is sick, in any way, our immune system will try and attack the illness but sometimes it overworks and will produce too much histamine thus causing hives. The best advice I have for you, is remember it could be much worse. I have hives and cervical cancer. I have been getting hives for 5 months now every single day, and the only thing that treats them is steroids and Xyzal, and let me tell you I have mood swings, gained 50 pounds, my bones hurt like you cant believe and my chest constantly feels like it's being hit with a baseball bat. Oh yeah and I have chronic GERD as well. Drink milk for that and avoid greasy food as much as possible. I get the same thing you do with the angiodema, and the blocking of the airways. I have been in the ER 4 times for it and i have thousands of dollars in bills to pay for all the blood testing my allergist had to do that my insurance wont cover because its hives. I'm only 20 years old, and I feel like I'm falling apart too. Strict diet and lots of cardio will make you feel a lot better if your willing to do that. Our bodies go back to the way they are supposed to be when we remove the bad food and exercise, because when you do exercise you heal yourself. xhttp://thyroid.about.com/b/2003/07/10/chronic-hives-linked-to-autoimmune-thyroid-disease.htm

By: Janet S.

Janet S. — Tue, 12 Aug 2008 10:59:34 +0000

I've just started taking Xyzal prescribed by an allergist. 1st pill last night. I've had CIU (hives) for a year now, since I had surgery to remove part of my thyroid. Have been to several Doctors, Endos, and no one even told me of this medicine. I've been on 20 mg Zyrtec daily, 300 mg Zantac daily (for H2 blocker), Claritin, Prednisone – you name it, but they've continued to strike along with angiodema, been to the hospital with blocked airway twice and now carry epipen wherever I go… I don't care if this drug is trumped up – desperate people will try anything to cure this damned condition! I'm hopeful that this will work… I also have chronic Gerd and am taking Prevacid along with Synthroid for my thyroid – 44 years old and falling apart at the seams. Anyone heard of thyroid problems causing hives?

By: RJS

RJS — Fri, 01 Aug 2008 14:32:36 +0000

The same reason Nexium and Prilosec work differently for a tiny percentage of the population: nobody knows. The human body is fickle, but I never said they were the same, because they're not.

By: Theresa

Theresa — Fri, 01 Aug 2008 13:11:12 +0000

The person who wrote this article is a moron. I have been getting chronic hives for over 4 months and I was taking Zyrtec twice a day in combination with Prednisone and let me tell you ZYRTEC IS GARBAGE. It did nothing to prevent me from getting hives and nothing for my everyday allergies. The very first day I took XYZAL there was a huge noticeable difference in my hives. The hives used to get in my throat and cover my body, now i might get a couple on my arms or stomach, but they are small. And the steroids that are so horrible got cut from 60mg a day to 5mg a day. Now if ZYRTEC AND XYZAL are the same, how come ZYRTEC didn't do the trick?

By: Jim Lee

Jim Lee — Sun, 04 Nov 2007 22:28:35 +0000

For years and I mean many years I've been trying anything that seemed the least be credible to rid myself of mucus causing me to clear my throat to the point I had do do so before every sentence. I've been to Stanford Medical Clinic, UC Davis and several doctors who have tried all types of pill, shots and treatments. I had given up. About a two months ago I saw an ad in the local paper asking the question "Lost you voice? Let us help." I said "oh sure" and moved on.

The ad, week after week, kept catching my eye so I decided to give it a try only to learn that it was for a medical group I'd all ready seen a couple of times about my problem with no noticable benefits.

I set an appointment anyway and up seeing the same doctor I said this visit is pointless and explained why. He did the routine investigation sticking a device up my nose and down to the vocal cord area and informed me things looked perfectly normal.

After much discussion he said well try this pill and gave me some free samples. It's new so who knows? The pill is Xyzal. I've taken it for two days now and my problem is 95 to a 100% resolved. I can't believe it. Will it last? I don't know. I certainly hope it will. I've done so many pills I'm near certain at one time Zyrtec was prescribed. I know Claritin and the spin offs do nothing at all for me. For now, from my perspective, Xyzal is a Godsend.

By: Warren

Warren — Wed, 24 Oct 2007 07:04:51 +0000

For those of us with chronic ideopathic urticaria, an isomer might just do the trick. I will gladly pay extra to get the relief I need rather than having to overdose on a combination of benedryl and zyrtec. The mirror image of the medicine might fit better into my H1-receptors – it's worth a shot!

By: jeff

jeff — Tue, 23 Oct 2007 01:21:51 +0000

First a few points:

Clarinex is the active metabolite of clarion. Clinical data between the two has been scarce and not much to report in terms of superiority either way.

Levocitirizine has been shown in several clinical studies (ie pollen chamber, receptor affinity models, and radiolabeled BBB analysis) to be both more potent and less sedating than zyrtec. The two drugs are similar and may not be worth giving them xyzal if they can get better on clariton or generic fex, but an alergist or ENT who knows the drug will be doing the potential paperwork to get thier patient on Levo.

By: RJS

RJS — Mon, 22 Oct 2007 00:25:51 +0000

Actually – no. Atarax/Zyrtec is like Claritin/Clarinex – they are metabolites the body will make one into another. Zyrtec/Xyzal is an isomer like Celexa/Lexapro. Totally different.

:confused:

Claritin: loratidine
Clarinex: desloratadine

Zyrtec: cetirizine
Xyzal: levocetirizine

Celexa: citalopram
Lexapro: escitalopram

The comparison works for all three drugs. Regardless of how it gets there, one is the racemic mixture, and the other is the racemic mixture.

By: S

Sun, 21 Oct 2007 23:07:17 +0000

Actually – no. Atarax/Zyrtec is like Claritin/Clarinex – they are metabolites the body will make one into another. Zyrtec/Xyzal is an isomer like Celexa/Lexapro. Totally different.

By: Eric

Eric — Mon, 15 Oct 2007 07:22:30 +0000

Actually, Reactine was Rx in Canada for at least a couple of years of life – certainly in the period before it was approved at all in the US – I was a lab rat for a Phase III and wanted to stay on it after (better relief than the other non-sedatings), so I made a trip up there…which must have been about 1993ish.

UCB ended up with a partnership with Sanofi for Xyzal specifically due to the OTC switch – Pfizer had some restrictions with the sale of the consumer business, I believe.

By: RJS

RJS — Sun, 14 Oct 2007 20:14:02 +0000

Ah. I heard rumors, and it was the next logical move, just like Claritin did.

Ironic because the price will fall through the floor whereas it's one of the most expensive antihistamines at the moment.

This pricing crap is Lame with a capital L.