Comments on: Best lab ever? Possibly. http://onthepharm.net/2008/10/dna-therapeutic-windows.html Life on the pharm Mon, 08 Mar 2010 22:13:46 -0800 http://wordpress.org/?v=2.8.6 hourly 1 By: Ida http://onthepharm.net/2008/10/dna-therapeutic-windows.html/comment-page-1#comment-181898 Ida Sun, 26 Oct 2008 21:06:36 +0000 http://onthepharm.net/?p=421#comment-181898 Medco and Mayo have teamed on a similar project, but I can speak to the commercially available assay and dosage calculator from Genelex in Seattle. Medco and Mayo have teamed on a similar project, but I can speak to the commercially available assay and dosage calculator from Genelex in Seattle.

]]> By: RJS http://onthepharm.net/2008/10/dna-therapeutic-windows.html/comment-page-1#comment-181894 RJS Sat, 25 Oct 2008 17:28:31 +0000 http://onthepharm.net/?p=421#comment-181894 Thanks for the information, Eric. I had no idea the rate of first-year hospitalization was so high, and indeed, when that is factored into the cost, this looks a lot more attractive. Thanks for the information, Eric. I had no idea the rate of first-year hospitalization was so high, and indeed, when that is factored into the cost, this looks a lot more attractive.

]]> By: eric http://onthepharm.net/2008/10/dna-therapeutic-windows.html/comment-page-1#comment-181893 eric Sat, 25 Oct 2008 17:08:46 +0000 http://onthepharm.net/?p=421#comment-181893 It's not the cost of the drug - it's the cost of the 29% of Warfarin users that are hospitalized in the first year due to a drug-related adverse event. Medco and Mayo have teamed on a similar project, but I can speak to the commercially available assay and dosage calculator from Genelex in Seattle. For about $500, you get the crucial p450 pathway genetics *and* the VKORC1 genetics. After that, plug in height, age, gender and the results to their calculator, and you get a weekly dose that is correct something like 85% of the time without titration. Results are ready in three days. My father-in-law was having a miserable time getting therapeutic - despite 100% compliance with his regime, weekly testing and use of a consistent manufacturer of Warfarin. I was skeptical at first, but he never had a non-therapeutic level again after the assay, and has never had a too-thin moment other than that associated with antibiotic use. This is going to keep people out of the hospital, no question in my mind. It's not the cost of the drug – it's the cost of the 29% of Warfarin users that are hospitalized in the first year due to a drug-related adverse event.

Medco and Mayo have teamed on a similar project, but I can speak to the commercially available assay and dosage calculator from Genelex in Seattle. For about $500, you get the crucial p450 pathway genetics *and* the VKORC1 genetics. After that, plug in height, age, gender and the results to their calculator, and you get a weekly dose that is correct something like 85% of the time without titration. Results are ready in three days.

My father-in-law was having a miserable time getting therapeutic – despite 100% compliance with his regime, weekly testing and use of a consistent manufacturer of Warfarin. I was skeptical at first, but he never had a non-therapeutic level again after the assay, and has never had a too-thin moment other than that associated with antibiotic use.

This is going to keep people out of the hospital, no question in my mind.

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